Thanks for the feedback, but I think you've misunderstood me. I meant "pile on attack runes of different colors" as attack runes that do not form any full sets, so I am not comparing the effectiveness of red rune sets versus other color rune sets on the vanilla characters. What I am saying is, it may be far better to utilize your attack runes of different colors to get a large increase in absolute ATK (and possibly no fullset bonus at all) rather than gather runes that are simply just all red, but are non-attack runes, for a 10% increase in base ATK.
For one, I agree with you that for Berserkers, with their innately high ATK, are much better contenders to focus on the 10% bonus. However, let's still try with your example. So according to your calculations, a lv 30+2 Ares Vinzerker would benefit 446ATK from having a full set of 4 red runes. For the most benefit of the doubt, we'll assume all the runes are 1-slot. A 4* attack rune of any color can easily go up to 120+ at +8 or so. So if you'd compare 4x 4*+8 red non-attack runes versus 4x 4*+8 non-red attack runes, it would be a marginal win for the non-red attack runes. Of course, like I said about Berserkers' naturally high base ATK, this is very marginal and you're absolutely right that in most cases Berserkers would benefit much more from just red rune set bonuses. However, if we see that even for a Ares Vinzerker it slightly favors non-red attack runes, then it is clear that for other Champion sub-classes such as Gladiators (or anything of a non-Ares faith), the margin is going to be much larger. It would probably require only 4* +5 non-red runes to justify their use at that point.
In conclusion, although the case you gave definitely was admittedly more difficult to justify using non-red runes of attack over red rune fullsets, there exist far more cases (even amongst Champion chars) that a char isn't as minmaxed on 1 stat as an Ares Berserker and would hence have much lower 10% bonus ATK on them.
You're committing a straw man fallacy by comparing red rune of non-attack with other rune color of attack.
For simple sake, we'll only use 4 rune and 1 slot each to compare.
4x 4* blue rune of attack = 222.6 def + 780 attack.
2x 4* red rune of def + 2x 4* red rune of attack = 559.5 atk+ 390 atk + 316 def (literally replace whatever color you want red rune still win out).
Conclusion: Red rune is best on a vinzerker. I want to say this is for every champion too but since I didn't check their stat I'm hesitant to make such conclusion.
If you going to compare, check the stat and actually write it out. And since you going to be misleading with the min-max concept, be sure to specify which stat you're comparing next time.
Your claim that I am committing a straw man fallacy is false because you have wrongly-assumed the comparisons that I am making. You think I am talking about comparisons between:
A. 4 attack runes of mixed color versus 4 attack runes of red color
or B. 4 attack runes of blue/green/yellow/pink versus 4 attack runes of red color
But I'm not. Simply because the answers to these two cases are really obvious, thus needing no discussion at all. In case A, the latter is ALWAYS better because the latter has everything the former has and more, making there be no room for discussion at all. It is also obvious that case B will simply be dependent on whichever stat is the char's highest base amount, so there's also not much room for discussion at all, as long as you designate a char. The only meaningful discussion is when it is NOT immediately clear which option to go for, which will be the case of 4 attack runes of mixed color versus 4 non-attack runes of red color. Only in such a case is there any space for consideration, isn't it?
I write to resolve difficult choices in the game whose answers are not immediately obvious, and they occur rather often as long as you aren't a whale who can get anything you want whenever you want. Your conclusion is absolutely, 100% correct in that red attack runes are the best runes on an Aresvinzerker, but exactly how useful is this piece of advice when I simply don't have so many 1 slot red attack runes to use? Most people would just have maybe 2 good red attack runes, 2-3 red non-attack runes and maybe 3 or 4 more attack runes of non-red color (that they don't need to use on other chars). Do I then, still try to get the full red set? This is a question that your calculations simply do not answer. Thus, it is an answer for an ideal situation, not a real, on-the-ground situation.
The reason I am talking about this instead of case A or B is not because I am straw-manning anything. I specifically chose to delve into such a question because it is simply because this a very real case. Usually when we try to put 4 red runes in a char, it is a real possibility that some of them, or even none of them will be attack runes, whereas we might have attack runes leftover from other rune colors. This is simply because it is far more possible to get attack runes of varying colors than attack runes of 1 single color in any series of runes. So what I'm trying to address is a very real problem that exists for most players that don't have access to exactly the best runes for every of their chars. People WILL have to make the decision between whether to sacrifice the fullset bonus of red runes and equip a few attack runes of different color, or sacrifice the raw attack bonuses of attack runes just to fulfill the 4 red rune set. This is a much more meaningful question to answer as compared to the question you answered, which is pretty much obvious even without having to do any calculations.
You should think about what problem does your simulation/calculation actually solves, does this actually help me make a decision in actual gameplay and do you actually have a meaningful problem statement before you do the calculations next time and save yourself some unnecessary work.